Dapoxetine and Sildenafil Tablets

Dapoxetine and Sildenafil Tablets is produced by Centurion. It is a combined medication that prevents men from ejaculating prematurely and helps to sustain an erection long enough for normal, satisfying sexual intercourse. Dapoxetine and Sildenafil Tablets contains two active ingredients  Sildenafil, a phosphodiesterase type 5 inhibitor, and Dapoxetine, short-acting serotonin reuptake inhibitor (SSRI).
Dapoxetine and Sildenafil Tablets 160 mg is a combination drug containing 100mg of Sildenafil citrate and 60mg of Dapoxetine hydrochloride, used in the treatment of erectile dysfunction and premature ejaculation in men 18 to 64 years of age. It helps men get and maintain erection and improve ejaculation time.
Sildenafil citrate belongs to the drug class called phosphodiesterase type 5 (PDE5) inhibitors. It works in helping men get and maintain an erection by increasing blood flow to the penis following sexual stimulation.
Dapoxetine on the other hand, is a serotonin-norepinephrine reuptake inhibitor (SNRI), an antidepressant that increases serotonin and norepinephrine levels. Serotonin is a neurotransmitter that is responsible in sending nerve messages that results in many body functions including ejaculation. Dapoxetine is a drug used in premature ejaculation. Premature ejaculation is a disorder where a man ejaculates before, during or shortly after penetration with minimal sexual stimulation even before a man even desires to do so. This drug improves control over ejaculation and increase time to ejaculation by increasing serotonin activity in the nervous system, delaying ejaculation reflex.
Usage of Dapoxetine and Sildenafil Tablets:
erectile dysfunction or impotence;
prematurity of ejaculation (PE).
Sildenafil is approved for the treatment of PAH (pulmonary arterial hypertension).
Dapoxetine and Sildenafil Tablets How To Work:
Sildenafil suppresses the enzyme phosphodiesterase type 5 (PDE-5). PDE-5 usually breaks down chemical messenger called cyclic GMP, which normally widens the blood vessels in the penis by relaxing muscles in the blood vessel walls. This delivers more blood to the penis, inducing a rigid erection. When the PDE-5 is inhibited, blood vessels are kept dilated longer, which improves blood flow to the penis and helps maintain an erection. Dapoxetine increases the activity of serotonin, a neurotransmitter that is involved in passing messages between nerve cells, including those that result in ejaculation. Enhanced activity of serotonin aids in increasing the time it takes to ejaculate and improves control over the ejaculation. Initially, Dapoxetine was created as an antidepressant.

Dosage of Dapoxetine and Sildenafil Tablets:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cenforce D Tablet may be taken with or without food, but it is better to take it at a fixed time.
 
Action of Dapoxetine and Sildenafil Tablets:
Physiology of penis erection defends upon the concentration of cGMP in presence of sexual stimulation. Cenforce being a cGMP specific PDE5 inhibitor promotes the activity of local nitric oxide by specifically inhibiting PDE5 enzyme (responsible for biodegradation of cGMP) in corpus cavernosum. Increase level of nitric acid and subsequently cGMP result in smooth muscle dilatation and increased influx of blood to the corpus cavernosum. Generic Sildenafil Citrate Tablets will only exhibit its effect in presence of sexual stimuli.